反应详情

A mixture of 9-chloro-3-methoxyacridine, (975 mg, 4 mmol), 3-aminophenethyl alcohol (549 mg, 4 ml) and methanesulfonic acid (0.32 ml, 5 mmol) in methanol (30 ml) is stirred under reflux for 2 hours. The mixture is concentrated in vacuo, and the residue is dissolved in methanol (10 ml). The solution is diluted with ether (150 ml). The precipitates are collected by filtration, washed with ether to give 9-[3'-(β-hydroxyethyl)anilino]-3-methoxyacridine, as the methanesulfonate (1.15 g, 65%), mp 186°-188° C.

1. temperatureunder reflux for 2 hours
2. concentrationThe mixture is concentrated in vacuo
3. dissolutionthe residue is dissolved in methanol (10 ml)
4. additionThe solution is diluted with ether (150 ml)
5. filtrationThe precipitates are collected by filtration
6. washwashed with ether