1-Propanone, 3-(dimethylamino)-1-phenyl-, hydrochloride (1:1) → 3-(Dimethylamino)-1-phenyl-1-propanone

HRID 484113Notes

Reaction equation

HRID 484113 reaction equation
Cl.[CH3:2][N:3]([CH3:14])[CH2:4][CH2:5][C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:7].C(=O)(O)[O-].[Na+]>ClCCl>[CH3:14][N:3]([CH3:2])[CH2:4][CH2:5][C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:7]

Participants

4

Reactant 2

HCID 928441-Propanone, 3-(dimethylamino)-1-phenyl-, hydrochloride (1:1)HCID 516892Sodium Bicarbonate

Product 1

HCID 770423-(Dimethylamino)-1-phenyl-1-propanoneYield 95.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-Dimethylaminopropiophenone hydrochloride (20 g) was treated with aqueous sodium bicarbonate solution in dichloromethane. The layers were separated and the organic phase was dried over anhydrous magnesium sulfate, filtered, and the filtrate was evaporated to provide 15.8 g of 3-dimethylaminopropiophenone.

Workup

  1. customThe layers were separated
  2. dry with materialthe organic phase was dried over anhydrous magnesium sulfate
  3. filtrationfiltered
  4. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-c31015e1aedd4ae3909301b4fe82740f
Source dataset
uspto-grants-1993_07
Patent number
US05229417

Reaction notes

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