2-Aminoindane → 4-(2-Indanylamino)-5-(2-thienyl)thieno[2,3-d]pyrimidine

HRID 48413Notes

Reaction equation

HRID 48413 reaction equation
Cl[C:2]1[C:3]2[C:10]([C:11]3[S:12][CH:13]=[CH:14][CH:15]=3)=[CH:9][S:8][C:4]=2[N:5]=[CH:6][N:7]=1.[NH2:16][CH:17]1[CH2:25][C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:18]1>>[CH2:18]1[C:19]2[C:24](=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:25][CH:17]1[NH:16][C:2]1[C:3]2[C:10]([C:11]3[S:12][CH:13]=[CH:14][CH:15]=3)=[CH:9][S:8][C:4]=2[N:5]=[CH:6][N:7]=1

Participants

3

Reactant 2

HCID 763102-AminoindaneHCID 7357324-Chloro-5-(2-thienyl)thieno[2,3-d]pyrimidine

Product 1

HCID 120940634-(2-Indanylamino)-5-(2-thienyl)thieno[2,3-d]pyrimidineYield 100%

Procedure

Using 4-chloro-5-(2-thienyl)thieno[2,3-d]pyrimidine (50 mg, 0.20 mmol) and 2-aminoindan (110 mg, 0.80 mmol), a similar procedure to Production Example 190 was carried out. The product obtained was purified by silica gel chromatography (hexane:ethyl acetate=1:1) to obtain the title compound (70 mg, 0.20 mmol) having the following physical properties:

Workup

  1. customThe product obtained
  2. customwas purified by silica gel chromatography (hexane:ethyl acetate=1:1)

Sources & evidence

ORD record
ord-af508c38ec2e46b0b21b9ae390a29200
Source dataset
uspto-grants-2004_03
Patent number
US06703421B1

Reaction notes

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