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HRID 484152作成日：2026年10月25日
Sodium Iodide → 3-[4-[1-(6-Chloro-1,2-benzisothiazol-3-yl)-4-piperazinyl]butyl]-2,5,5-trimethyl-4-thiazolidinone hydrochloride
https://huagongshe.com/reaction/484152
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Iodide | HCID 5238 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 6-Chloro-1,2-benzisothiazol-3-yl piperazine | HCID 10491125 | — |
| 反応物 | 3-(4-Bromobutyl)-2,5,5-trimethyl-4-thiazolidinone | HCID 10779094 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 3-[4-[1-(6-Chloro-1,2-benzisothiazol-3-yl)-4-piperazinyl]butyl]-2,5,5-trimethyl-4-thiazolidinone hydrochloride | HCID 14856154 | 132.1% |
反応手順
A mixture of 3-(4-bromobutyl)-2,5,5-trimethyl-4-thiazolidinone (3.6 g), 6-chloro-1,2-benzisothiazol-3-yl piperazine (3.7 g), K2CO3 (4.0 g) and NaI (200 mg) in CH3CN (175 ml) was heated at 80° C. for 18 hours and the product was processed in substantially the same manner as in Example 10 to afford 4.714 g of product, m.p. 204°-206° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05229388 |
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| 出典データセット | uspto-grants-1993_07 |
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| ORD ID | ord-83a12f3ee9ac424f8a0b897d35c7785a |
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| 出典メモ | uspto-grants-1993_07 |
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