Sodium Iodide → 3-(4-(1-(1,1-dioxo-1,2-Benzisothiazol-3-yl)-4-piperazinyl)butyl)-1-thia-3-azaspiro[4.4]nonan-4-one

Participants

Role	Name	HCID	Charge
Reactant	Sodium Iodide	HCID 5238	—
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	3-(Piperazin-1-yl)-1,2-benzothiazole-1,1-dione	HCID 695718	—
Reactant	3-(4-Bromobutyl)-1-thia-3-azaspiro[4.4]nonan-4-one	HCID 10708747	—
Solvent	Acetonitrile	HCID 6342	—
Product	3-(4-(1-(1,1-dioxo-1,2-Benzisothiazol-3-yl)-4-piperazinyl)butyl)-1-thia-3-azaspiro[4.4]nonan-4-one	HCID 10576037	52.2%

Reaction Conditions

Temperature	85 °C

Reaction Steps

A mixture of 3-(4-bromobutyl)-1-thia-3-azaspiro[4.4]-nonan-4-one (3.50 g), 1-(1,1-dioxo-1,2-benzisothiazol-3-yl)piperazine (3.30 g), K2CO3 (4.98 g) and NaI (280 mg) in acetonitrile (230 ml) was heated at 85° C. for 20 hours and the product was processed in substantially the same manner as in Example 10 to afford 2.89 g of needles, m.p. 137°-140° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05229388
Source dataset	uspto-grants-1993_07
ORD ID	ord-7e46a4a07a724fd7a89f5b8c6ed1389c
Source note	uspto-grants-1993_07