HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 11550077, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-Chloro-2-chloromethyl-4-cyano-4-methylbutyraldehyde | HCID 19751084 | — |
| Catalyst | Nickel Dichloride | HCID 24385 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 11550077 | HCID 11550077 | — |
Reaction Steps
4 grams of 2-chloro-2-chloromethyl-4-cyano-4-methylbutyraldehyde dissolved in 30 mL of acetonitrile is pumped concomitantly with anhydrous HCl into a pre-heated (180°-230° C.) flow reactor packed with NiCl2 -impregnated clay. Short path distillation gives 2-chloro-3-methyl-5-chloromethylpyridine as a liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05229519 |
| Source dataset | uspto-grants-1993_07 |
| ORD ID | ord-286870e15ded4d7a9e30dce80e32a824 |
| Source note | uspto-grants-1993_07 |