Hydrochloric Acid → HCID 11550077, compound

HRID 484219Notes

Reaction equation

HRID 484219 reaction equation
Cl[C:2]([CH2:10][Cl:11])([CH2:5][CH:6]([C:8]#[N:9])[CH3:7])[CH:3]=O.[ClH:12]>C(#N)C.Cl[Ni]Cl>[Cl:12][C:8]1[C:6]([CH3:7])=[CH:5][C:2]([CH2:10][Cl:11])=[CH:3][N:9]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 197510842-Chloro-2-chloromethyl-4-cyano-4-methylbutyraldehyde

Product 1

HCID 11550077HCID 11550077, compound

Reagents, catalysts & solvents 2

HCID 24385Nickel DichlorideCatalystHCID 6342AcetonitrileSolvent

Procedure

4 grams of 2-chloro-2-chloromethyl-4-cyano-4-methylbutyraldehyde dissolved in 30 mL of acetonitrile is pumped concomitantly with anhydrous HCl into a pre-heated (180°-230° C.) flow reactor packed with NiCl2 -impregnated clay. Short path distillation gives 2-chloro-3-methyl-5-chloromethylpyridine as a liquid.

Workup

  1. temperaturea pre-heated (180°-230° C.) flow reactor
  2. distillationShort path distillation

Sources & evidence

ORD record
ord-286870e15ded4d7a9e30dce80e32a824
Source dataset
uspto-grants-1993_07
Patent number
US05229519

Reaction notes

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