1,4-Dioxane hydrochloride → 2-Amino-5-phenoxyindan hydrochloride

HRID 48422Notes

Reaction equation

HRID 48422 reaction equation
C(OC([NH:8][CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH:15]=2)[CH2:10]1)=O)(C)(C)C.[ClH:25].O1CCOCC1>C(O)(=O)C>[ClH:25].[NH2:8][CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:18][C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH:15]=2)[CH2:10]1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 227195862-(Tert-butoxycarbonylamino)-5-phenoxyindan

Product 1

HCID 227196152-Amino-5-phenoxyindan hydrochloride

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Using 2-(tert-butoxycarbonylamino)-5-phenoxyindan (120 mg, 0.36 mmol), 4N hydrochloric acid-dioxane (1.7 ml) and acetic acid (5.1 ml), a similar procedure to Production Example 213 was carried out to obtain 2-amino-5-phenoxyindan hydrochloride (99 mg, 0.36 mmol) having the following physical properties:

Sources & evidence

ORD record
ord-269fb28bf0074a1c92198459c2a84f84
Source dataset
uspto-grants-2004_03
Patent number
US06703421B1

Reaction notes

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