Triethylamine → HCID 19746942, compound

HRID 484290Notes

Reaction equation

HRID 484290 reaction equation
Cl[P:2]1[O:7][CH2:6][C:5]2([CH2:12][O:11][P:10](Cl)[O:9][CH2:8]2)[CH2:4][O:3]1.[CH3:14][NH:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33].C([N:36]([CH2:39]C)[CH2:37][CH3:38])C>C1(C)C=CC=CC=1>[CH3:14][N:15]([P:2]1[O:7][CH2:6][C:5]2([CH2:12][O:11][P:10]([N:36]([CH2:37][CH2:38][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH3:16])[CH3:39])[O:9][CH2:8]2)[CH2:4][O:3]1)[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 75539N-MethyloctadecylamineHCID 772022,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9-dichloro-

Product 1

HCID 19746942HCID 19746942, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The procedure of Example 1 is repeated using 18.4 g (70 mmol) of 3,9-dichloro-2,4,8,10-tetraoxa-3,9-diphosphaspiro[5.5]undecane, 39.5 g (140 mmol) of N-methyl-N-octadecylamine and 19.5 mL (140 mmol) of triethylamine in 250 mL of toluene to give a crude reaction residue. The residue is purified by recrystallization from a mixture of toluene and acetonitrile to give 32 g (64% yield) of the title compound as an off-white solid melting at 70°-72° C.

Workup

  1. customto give a crude
  2. customreaction residue
  3. customThe residue is purified by recrystallization from a mixture of toluene and acetonitrile

Sources & evidence

ORD record
ord-26859070d3b94aa39b90d58e6c44c826
Source dataset
uspto-grants-1993_07
Patent number
US05230816

Reaction notes

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