1,4-Dioxane hydrochloride → N-benzyl-2-amino-5-indan carboxamide hydrochloride

HRID 48432Notes

Reaction equation

HRID 48432 reaction equation
[CH2:1]([NH:8][C:9]([C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[CH2:16][CH:15]([NH:20]C(OC(C)(C)C)=O)[CH2:14]2)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:28].O1CCOCC1>C(O)(=O)C>[ClH:28].[CH2:1]([NH:8][C:9]([C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[CH2:16][CH:15]([NH2:20])[CH2:14]2)=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 22719645N-benzyl-2-(tert-butoxycarbonylamino)-5-indan carboxamide

Product 1

HCID 22719605N-benzyl-2-amino-5-indan carboxamide hydrochloride

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Using N-benzyl-2-(tert-butoxycarbonylamino)-5-indan carboxamide (820 mg, 2.2 mmol), 4N hydrochloric acid-dioxane (10 ml) and acetic acid (30 ml), a similar procedure to Production Example 213 was carried out to obtain N-benzyl-2-amino-5-indan carboxamide hydrochloride (660 mg, 2.2 mmol) having the following physical properties:

Sources & evidence

ORD record
ord-34e3df64b6094d4695de6fdcb50d62d6
Source dataset
uspto-grants-2004_03
Patent number
US06703421B1

Reaction notes

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