Carbon Dioxide → 124728-46-7

HRID 484321Notes

Reaction equation

HRID 484321 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[F:8].[CH:9](=O)[CH2:10][CH3:11].[C:13](=[O:15])=[O:14]>>[F:1][C:2]1[C:3]([F:8])=[C:4]([CH2:9][CH2:10][CH3:11])[CH:5]=[CH:6][C:7]=1[C:13]([OH:15])=[O:14]

Participants

4

Reactant 3

HCID 280Carbon DioxideHCID 527PropanalHCID 97061,2-Difluorobenzene

Product 1

HCID 14495800124728-46-7

Procedure

2,3-Difluoropropylbenzene is obtained by lithiating o-difluorobenzene at -70° to -80° and reacting with propionaldehyde, dehydrating the secondary alcohol produced and subsequently hydrogenating the double bond. Re-metallation and reaction with dry ice gives 2,3-difluoro-4-propylbenzoic acid. From this acid, 4-(4'-pentylbiphenyl) 2,3-difluoro-4-propylbenzoate, C 74° Sc 86° N 160.1° I, is obtained analogously to Example 1 by esterification using 4-pentyl-4'-hydroxybiphenyl anddicyclohexylcarbodiimide.

Workup

  1. customat -70° to -80°
  2. customproduced

Sources & evidence

ORD record
ord-d2c723d541d44e70a02ef285c58bf3e5
Source dataset
uspto-grants-1993_07
Patent number
US05230827

Reaction notes

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