HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosgene → Dabco
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosgene | HCID 6371 | — |
| Reactant | Methyl chloroformate | HCID 6586 | — |
| Reactant | Benzyl chloroformate | HCID 10387 | — |
| Reactant | Ethyl chloroformate | HCID 10928 | — |
| Reactant | Bis-(1H-imidazol-2-YL)-methanone | HCID 5250894 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | Dabco | HCID 9237 | — |
| Product | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Product | Diisopropylethylamine | HCID 81531 | — |
Reaction Steps
The compound (V) is reacted with a carbonic ester (e.g. diethyl carbonate, dimethyl carbonate, benzyl carbonate) in the presence of a base (e.g. lithium carbonate, sodium carbonate, potassium carbonate, sodium hydroxide, potassium hydroxide, sodium methoxide, sodium ethoxide, diisopropylethylamine, triethylamine) to produce the compound (VI). Alternatively, the compound (V) is reacted with phosgene, methyl chlorocarbonate, ethyl chlorocarbonate, benzyl chlorocarbonate or carbonyl diimidazole or its related compound, if necessary, in the presence of a base (e.g. triethylamine, diisopropylethylamine, 1,4-di azabicyclo[2.2.2]octane, 1,8-diazabicyclo[5.4.0]undec-7-ene) to give the compound (VI).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05231179 |
| Source dataset | uspto-grants-1993_07 |
| ORD ID | ord-755d66e8515f4c249a3065dd09fd5f46 |
| Source note | uspto-grants-1993_07 |