1,4-Dioxane hydrochloride → 5-Benzoyloxy-2-aminoindan hydrochloride

HRID 48444Notes

Reaction equation

HRID 48444 reaction equation
[C:1]([O:9][C:10]1[CH:11]=[C:12]2[C:16](=[CH:17][CH:18]=1)[CH2:15][CH:14]([NH:19]C(OC(C)(C)C)=O)[CH2:13]2)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:27].O1CCOCC1>C(O)(=O)C>[ClH:27].[C:1]([O:9][C:10]1[CH:11]=[C:12]2[C:16](=[CH:17][CH:18]=1)[CH2:15][CH:14]([NH2:19])[CH2:13]2)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 22719618HCID 22719618, compound

Product 1

HCID 227195955-Benzoyloxy-2-aminoindan hydrochloride

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Using 5-benzoyloxy-2-(tert-butoxycarbonylamino)indan (130 mg, 0.37 mmol), 4N hydrochloric acid-dioxane (2 ml) and acetic acid (6 ml), a similar procedure to Production Example 213 was carried out to obtain 5-benzoyloxy-2-aminoindan hydrochloride (67 mg, 0.35 mmol) having the following physical properties:

Sources & evidence

ORD record
ord-9000e9d512c5426bacd14693b2e40f75
Source dataset
uspto-grants-2004_03
Patent number
US06703421B1

Reaction notes

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