Alanine-methacrylamide → HCID 178449942, compound

HRID 48453Notes

Reaction equation

HRID 48453 reaction equation
Cl.[C:2]([NH2:7])(=[O:6])[C:3]([CH3:5])=[CH2:4].[NH2:8][C@H:9]([C:17]([OH:19])=[O:18])[CH2:10][CH2:11][CH2:12][NH:13][C:14](=[NH:16])[NH2:15].[C:20]([NH2:25])(=[O:24])[C:21]([CH3:23])=[CH2:22].N[C@H](C(O)=O)C>O>[C:2]([NH2:7])(=[O:6])[C:3]([CH3:5])=[CH2:4].[NH2:8][C@H:9]([C:17]([OH:19])=[O:18])[CH3:10].[C:20]([NH2:25])(=[O:24])[C:21]([CH3:23])=[CH2:22].[NH2:8][C@H:9]([C:17]([OH:19])=[O:18])[CH2:10][CH2:11][CH2:12][NH:13][C:14](=[NH:15])[NH2:16]

Participants

4

Reactant 2

HCID 86759378Alanine-methacrylamideHCID 178449946HCID 178449946, compound

Product 1

HCID 178449942HCID 178449942, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Arginine-methacrylamide hydrochloride(10.53 g) and 13.90 g of the aforementioned alanine-methacrylamide were dissolved in 100 ml of distilled water, and bubbled with nitrogen gas for 1 hour. Potassium persulfate(250 mg) was added to the solution, and dissolved in it. The reaction mixture was refluxed by heating for 3 hours, then cooled to room temperature, and poured into acetone, so that precipitates were deposited. The supernatant was discarded, and acetone was again added to the precipitates and obtained mixture was stirred. The deposition was collected by filtration and dried to obtain the target polymer (white powder, 20.90 g).

Workup

  1. custombubbled with nitrogen gas for 1 hour
  2. additionPotassium persulfate(250 mg) was added to the solution
  3. dissolutiondissolved in it
  4. temperatureThe reaction mixture was refluxed
  5. temperatureby heating for 3 hours
  6. additionpoured into acetone
  7. customso that precipitates
  8. additionacetone was again added to the
  9. customprecipitates
  10. customobtained mixture
  11. filtrationThe deposition was collected by filtration
  12. customdried
  13. customto obtain the target polymer (white powder, 20.90 g)

Sources & evidence

ORD record
ord-2dbb898dd13a4e53b69224bbf57f53a4
Source dataset
uspto-grants-2004_03
Patent number
US06703468B1

Reaction notes

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