反应详情

A mixture of 46.5 g of 3-hydroxybenzeneacetic acid methyl ester, 77.6 g n-tetradecyl bromide and 42.54 g of potassium carbonate in 500 ml of acetone is refluxed for 24 hours. Another 15.5 g of potassium carbonate is added and reflux continued for another 24 hours. An additional 15.5 g of potassium carbonate is added and reflux continued for another 24 hours. The mixture is filtered and the filtrate evaporated to a residue which is poured into water and extracted with ether. The organic layer is dried and evaporated to a residue which is crystallized from hexane to give 45 g of the desired product as a white solid, m.p. 31°-33° C.

1. temperatureis refluxed for 24 hours
2. temperaturereflux
3. temperaturereflux
4. waitcontinued for another 24 hours
5. filtrationThe mixture is filtered
6. customthe filtrate evaporated to a residue which
7. additionis poured into water
8. extractionextracted with ether
9. customThe organic layer is dried
10. customevaporated to a residue which
11. customis crystallized from hexane