反应详情

To a 0° C. solution of 13 g of p-(tetradecyloxy)phenyl isocyanate in 70 ml of tetrahydrofuran and 30 ml of pyridine is added over 10 minutes a solution of 7.24 g of 3-aminobenzyl alcohol in 70 ml of tetrahydrofuran with continued stirring for one hour. The mixture is heated until all the solids dissolve then allowed to stand at ambient temperature overnight. The mixture is poured into water and the solid collected. The solid is washed with dilute hydrochloric acid and Water then crystallized from ethyl alcohol to give 13.1 g of the desired product as a light pink solid, m.p. 150°-158° C.

1. temperatureThe mixture is heated until all the solids
2. dissolutiondissolve
3. waitto stand at ambient temperature overnight
4. customthe solid collected
5. washThe solid is washed with dilute hydrochloric acid and Water
6. customthen crystallized from ethyl alcohol