2-Amino-6-Chloropyrazine → HCID 54703122, compound

HRID 484685Notes

Reaction equation

HRID 484685 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:10](=[O:12])(=[O:11])[N:9]([CH3:13])[C:8]([C:14]([O:16]C)=O)=[C:7]([OH:18])[C:6]=2[CH:19]=1.[NH2:20][C:21]1[CH:26]=[N:25][CH:24]=[C:23]([Cl:27])[N:22]=1>C1(C)C(C)=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:10](=[O:11])(=[O:12])[N:9]([CH3:13])[C:8]([C:14]([NH:20][C:21]3[CH:26]=[N:25][CH:24]=[C:23]([Cl:27])[N:22]=3)=[O:16])=[C:7]([OH:18])[C:6]=2[CH:19]=1

Participants

4

Reactant 2

HCID 1184582-Amino-6-ChloropyrazineHCID 54703139HCID 54703139, compound

Product 1

HCID 54703122HCID 54703122, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

3.04 (10 mmols) of methyl 6-chloro-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate-1,1-dioxide and 1.5 g (12 mmols) of 2-amino-6-chloro-pyrazine were reacted in 150 ml of xylene analogous to Example 2. 3.2 g (80% of theory) of 6-chloro-N-(6-chloro-pyrazin-2-yl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide were obtained.

Sources & evidence

ORD record
ord-65143e5e5bc24de5a2b1b57569befcf8
Source dataset
uspto-grants-1985_08
Patent number
US04533664

Reaction notes

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