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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 484693Generated: October 28, 2026

p-Toluenesulfonic acid → N-(6-chloro-pyrazin-2-yl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide

https://huagongshe.com/reaction/484693

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-Toluenesulfonic acidHCID 6101—
Reactant2-Amino-6-ChloropyrazineHCID 118458—
ReactantHCID 54703126HCID 54703126—
ProductN-(6-chloro-pyrazin-2-yl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxideHCID 54703135—

Reaction Steps

This compound was prepared from 4-hydroxy-2-methyl-N-ethyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide, 2-amino-6-chloro-pyrazine and p-toluenesulfonic acid analogous to Example 14.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04533664
Source datasetuspto-grants-1985_08
ORD IDord-116895e6eb5b4ff0a026d5649a42ad45
Source noteuspto-grants-1985_08