p-Toluenesulfonic acid → N-(6-chloro-pyrazin-2-yl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide

HRID 484693Notes

Reaction equation

HRID 484693 reaction equation
[OH:1][C:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[S:5](=[O:13])(=[O:12])[N:4]([CH3:14])[C:3]=1[C:15]([NH:17][CH2:18][CH3:19])=[O:16].NC1C=[N:25][CH:24]=[C:23]([Cl:27])[N:22]=1.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[Cl:27][C:23]1[N:22]=[C:18]([NH:17][C:15]([C:3]2[N:4]([CH3:14])[S:5](=[O:12])(=[O:13])[C:6]3[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=3[C:2]=2[OH:1])=[O:16])[CH:19]=[N:25][CH:24]=1

Participants

4

Reactant 3

HCID 6101p-Toluenesulfonic acidHCID 1184582-Amino-6-ChloropyrazineHCID 54703126HCID 54703126, compound

Product 1

HCID 54703135N-(6-chloro-pyrazin-2-yl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide

Procedure

This compound was prepared from 4-hydroxy-2-methyl-N-ethyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide, 2-amino-6-chloro-pyrazine and p-toluenesulfonic acid analogous to Example 14.

Sources & evidence

ORD record
ord-116895e6eb5b4ff0a026d5649a42ad45
Source dataset
uspto-grants-1985_08
Patent number
US04533664

Reaction notes

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