Ethoxy(6-phthalimidohexyl)phosphinyl chloride → (S)-3-[[ethoxy(6-phthalimidohexyl)phosphinyl]amino]-2-oxo-1-piperidineacetic acid, ethyl ester

HRID 484762Notes

Reaction equation

HRID 484762 reaction equation
[CH2:1]([O:3][P:4](Cl)([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][N:12]1[C:16](=[O:17])[C:15]2=[CH:18][CH:19]=[CH:20][CH:21]=[C:14]2[C:13]1=[O:22])=[O:5])[CH3:2].[NH2:24][C@H:25]1[CH2:30][CH2:29][CH2:28][N:27]([CH2:31][C:32]([O:34][CH2:35][CH3:36])=[O:33])[C:26]1=[O:37]>>[CH2:1]([O:3][P:4]([NH:24][C@H:25]1[CH2:30][CH2:29][CH2:28][N:27]([CH2:31][C:32]([O:34][CH2:35][CH3:36])=[O:33])[C:26]1=[O:37])([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][N:12]1[C:16](=[O:17])[C:15]2=[CH:18][CH:19]=[CH:20][CH:21]=[C:14]2[C:13]1=[O:22])=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 256577Ethoxy(6-phthalimidohexyl)phosphinyl chlorideHCID 13556450(S)-3-Amino-2-oxo-1-piperidineacetic acid, Ethyl ester

Product 1

HCID 86740217(S)-3-[[ethoxy(6-phthalimidohexyl)phosphinyl]amino]-2-oxo-1-piperidineacetic acid, ethyl ester

Procedure

Ethoxy(6-phthalimidohexyl)phosphinyl chloride and (S)-3-amino-2-oxopiperidineacetic acid, ethyl ester are reacted according to the procedure of Example 1(g) to give (S)-3-[[ethoxy(6-phthalimidohexyl)phosphinyl]amino]-2-oxo-1-piperidineacetic acid, ethyl ester.

Sources & evidence

ORD record
ord-abfd7da1fbfd46b88c12907ff29a562e
Source dataset
uspto-grants-1985_08
Patent number
US04533661

Reaction notes

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