反应详情

In a sealed tube, 10 g of the 4-phenoxy-2-butyl tosylate was reacted with 11.2 g of piperidine in 60 ml of absolute methyl alcohol for one hour at 125° C. After the reaction solution was condensed under reduced pressure, 100 ml of diethyl ether was added into the solution, and then the solution was separated into the diethyl ether solution and 20% aqueous sodium hydroxide solution. After the ether layer was dried over anhydrous sodium sulfate, ether was removed under reduced pressure therefrom. The residue thus obtained was subjected to an alumina-column chromatography using chloroform as the developing solvent to give 5.46 g of 1-(1-methyl-3-phenoxypropyl)piperidine in a yield of 75%.

1. additionwas added into the solution
2. customthe solution was separated into the diethyl ether solution and 20% aqueous sodium hydroxide solution
3. dry with materialAfter the ether layer was dried over anhydrous sodium sulfate, ether
4. customwas removed under reduced pressure
5. customThe residue thus obtained