反应详情

5 g of the 1-methyl-3-phenoxypropyldimethylamine thus obtained was reacted with 30 ml of 40% hydrobromic acid at 150° C. for 7 hours with stirring. The reaction solution was cooled and added with 20 ml of chloroform, and then the hydrobromic acid layer was separated from the chloroform layer. The hydrobromic acid was removed under reduced pressure and the residue was recrystallized from 5 ml of ethyl alcohol to give 4.46 g of 1-methyl-3-bromopropyldimethylamine hydrobromide in a yield of 79%.

1. temperatureThe reaction solution was cooled
2. customthe hydrobromic acid layer was separated from the chloroform layer
3. customThe hydrobromic acid was removed under reduced pressure
4. customthe residue was recrystallized from 5 ml of ethyl alcohol