Hydrochloric Acid → 1-(3-Diethylaminopropyl)-3-amino-4-hydroxyindazole dihydrochloride

HRID 484846Notes

Reaction equation

HRID 484846 reaction equation
[CH2:1]([N:3]([CH2:18][CH3:19])[CH2:4][CH2:5][CH2:6][N:7]1[C:15]2[C:10](=[C:11]([OH:16])[CH:12]=[CH:13][CH:14]=2)[C:9]([NH2:17])=[N:8]1)[CH3:2].[ClH:20].C(OCC)C>C(O)C>[ClH:20].[ClH:20].[CH2:18]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][CH2:6][N:7]1[C:15]2[C:10](=[C:11]([OH:16])[CH:12]=[CH:13][CH:14]=2)[C:9]([NH2:17])=[N:8]1)[CH3:19]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 1355831011-(3-Diethylaminopropyl)-3-amino-4-hydroxyindazole

Product 1

HCID 1355831101-(3-Diethylaminopropyl)-3-amino-4-hydroxyindazole dihydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 50 ml of absolute ethyl alcohol was dissolved 3.0 g of 1-(3-diethylaminopropyl)-3-amino-4-hydroxyindazole, and into the solution was introduced dried hydrogen chloride gas under cooling with ice. To the solution was added anhydrous diethyl ether to separate crystals. Then the crystals were obtained by filtration and dried to give 1-(3-diethylaminopropyl)-3-amino-4-hydroxyindazole dihydrochloride having the following analytical value.

Workup

  1. temperatureunder cooling with ice
  2. customto separate crystals
  3. customThen the crystals were obtained by filtration
  4. customdried

Sources & evidence

ORD record
ord-61a73d3b2be94be1999d22bbdbdd29c5
Source dataset
uspto-grants-1985_08
Patent number
US04533731

Reaction notes

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