Hydrochloric Acid → 1,3-Propanediamine,n3-(4-chloro-1h-indazol-3-yl)-n1,n1-diethyl-,hydrochloride

HRID 484853Notes

Reaction equation

HRID 484853 reaction equation
[CH2:1]([N:3]([CH2:6][CH2:7][CH2:8][NH:9][C:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][C:17]=2[Cl:19])[NH:12][N:11]=1)[CH2:4][CH3:5])[CH3:2].Cl.C(OCC)C>C(O)C>[ClH:19].[CH2:4]([N:3]([CH2:1][CH3:2])[CH2:6][CH2:7][CH2:8][NH:9][C:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][C:17]=2[Cl:19])[NH:12][N:11]=1)[CH3:5]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 201358471,3-Propanediamine,n3-(4-chloro-1h-indazol-3-yl)-n1,n1-diethyl-

Product 1

HCID 201359221,3-Propanediamine,n3-(4-chloro-1h-indazol-3-yl)-n1,n1-diethyl-,hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 50 ml of absolute ethyl alcohol was dissolved 4.0 g of 3-(diethylaminopropylamino)-4-chloroindazole and into the solution was introduced dried hydrogen chloride gas under cooling with ice. To the solution was added anhydrous diethyl ether to separate crystals. Then the crystals were obtained by filtration and dried to give 3-(3-diethylaminopropylamino)-4-chloroindazole hydrochloride having the following analytical value.

Workup

  1. temperatureunder cooling with ice
  2. customto separate crystals
  3. customThen the crystals were obtained by filtration
  4. customdried

Sources & evidence

ORD record
ord-592d107c828d4e89b36a384aa5e9eebc
Source dataset
uspto-grants-1985_08
Patent number
US04533731

Reaction notes

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