Hydrochloric Acid → 1-(3-Diethylaminopropyl)-3-(3-diethylaminopropylamino)-5-aminoindazole trihydrochloride

HRID 484875Notes

Reaction equation

HRID 484875 reaction equation
[CH2:1]([N:3]([CH2:26][CH3:27])[CH2:4][CH2:5][CH2:6][N:7]1[C:15]2[C:10](=[CH:11][C:12]([NH2:16])=[CH:13][CH:14]=2)[C:9]([NH:17][CH2:18][CH2:19][CH2:20][N:21]([CH2:24][CH3:25])[CH2:22][CH3:23])=[N:8]1)[CH3:2].[ClH:28].C(OCC)C>C(O)C>[ClH:28].[ClH:28].[ClH:28].[CH2:26]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][CH2:6][N:7]1[C:15]2[C:10](=[CH:11][C:12]([NH2:16])=[CH:13][CH:14]=2)[C:9]([NH:17][CH2:18][CH2:19][CH2:20][N:21]([CH2:22][CH3:23])[CH2:24][CH3:25])=[N:8]1)[CH3:27]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 201358371-(3-Diethylaminopropyl)-3-(3-diethylaminopropylamino)-5-aminoindazole

Product 1

HCID 201358791-(3-Diethylaminopropyl)-3-(3-diethylaminopropylamino)-5-aminoindazole trihydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 15 ml of absolute ethyl alcohol was dissolved 0.7 g of the 1-(3-diethylaminopropyl)-3-(3-diethylaminopropylamino)-5-aminoindazole, and into the solution was introduced dried hydrogen chloride gas under cooling with ice. Then to the solution was added anhydrous diethyl ether to separate crystals. The crystals were obtained by filtration and dried to give 1-(3-diethylaminopropyl)-3-(3-diethylaminopropylamino)-5-aminoindazole trihydrochloride having the following analytical value.

Workup

  1. temperatureunder cooling with ice
  2. customto separate crystals
  3. customThe crystals were obtained by filtration
  4. customdried

Sources & evidence

ORD record
ord-6b1ef591783e416a85d1c79dcde1b172
Source dataset
uspto-grants-1985_08
Patent number
US04533731

Reaction notes

Loading…