Hydrochloric Acid → 1-(3-Morpholinopropyl)-3-(3-diethylaminopropylamino)-5-chloroindazole dihydrochloride

HRID 484888Notes

Reaction equation

HRID 484888 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][CH2:9][N:10]2[C:18]3[C:13](=[CH:14][C:15]([Cl:19])=[CH:16][CH:17]=3)[C:12]([NH:20][CH2:21][CH2:22][CH2:23][N:24]([CH2:27][CH3:28])[CH2:25][CH3:26])=[N:11]2)[CH2:3][CH2:2]1.[ClH:29].C(OCC)C>C(O)C>[ClH:19].[ClH:29].[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][CH2:9][N:10]2[C:18]3[C:13](=[CH:14][C:15]([Cl:19])=[CH:16][CH:17]=3)[C:12]([NH:20][CH2:21][CH2:22][CH2:23][N:24]([CH2:27][CH3:28])[CH2:25][CH3:26])=[N:11]2)[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 201358241-(3-Morpholinopropyl)-3-(3-diethylaminopropylamino)-5-chloroindazole

Product 1

HCID 201358651-(3-Morpholinopropyl)-3-(3-diethylaminopropylamino)-5-chloroindazole dihydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 50 ml of absolute ethyl alcohol was dissolved 3.2 g of the 1-(3-morpholinopropyl)-3-(3-diethylaminopropylamino)-5-chloroindazole, and into the solution was introduced dried hydrogen chloride gas under cooling with ice. Then to the solution was added anhydrous diethyl ether to separate crystals. The crystals were obtained by filtration and dried to give 1-(3-morpholinopropyl)-3-(3-diethylaminopropylamino)-5-chloroindazole dihydrochloride having the following analytical value.

Workup

  1. temperatureunder cooling with ice
  2. customto separate crystals
  3. customThe crystals were obtained by filtration
  4. customdried

Sources & evidence

ORD record
ord-2c32ec08ba4044138795cc94f359efbf
Source dataset
uspto-grants-1985_08
Patent number
US04533731

Reaction notes

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