Hydrochloric Acid → HCID 20135818, compound

HRID 484905Notes

Reaction equation

HRID 484905 reaction equation
[CH3:1][N:2]([CH3:26])[CH:3]([CH3:25])[CH2:4][CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([OH:15])=[CH:12][CH:13]=2)[C:8]([NH:16][CH2:17][CH2:18][CH2:19][N:20]([CH2:23][CH3:24])[CH2:21][CH3:22])=[N:7]1.[ClH:27].C(OCC)C>C(O)C>[ClH:27].[ClH:27].[CH3:26][N:2]([CH3:1])[CH:3]([CH3:25])[CH2:4][CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([OH:15])=[CH:12][CH:13]=2)[C:8]([NH:16][CH2:17][CH2:18][CH2:19][N:20]([CH2:23][CH3:24])[CH2:21][CH3:22])=[N:7]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 13210621HCID 13210621, compound

Product 1

HCID 20135818HCID 20135818, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 50 ml of absolute ethyl alcohol was dissolved 3.8 g of the 1-(3-dimethylaminobutyl)-3-(3-diethylaminopropylamino)-5-hydroxyindazole, and into the solution was introduced dried hydrogen chloride gas under cooling with ice. Then to the solution was added anhydrous diethyl ether to separate crystals. The crystals were obtained by filtration and dried to give 1-(3-dimethylaminobutyl)-3-(3-diethylaminopropylamino)-5-hydroxyindazole dihydrochloride having the following analytical value.

Workup

  1. temperatureunder cooling with ice
  2. customto separate crystals
  3. customThe crystals were obtained by filtration
  4. customdried

Sources & evidence

ORD record
ord-7df9fd9f232849d6a5753aac97965971
Source dataset
uspto-grants-1985_08
Patent number
US04533731

Reaction notes

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