Hydrochloric Acid → 1-(3-Morpholinopropyl)-3-(3-diethylaminopropylamino)indazole dihydrochloride

HRID 484912Notes

Reaction equation

HRID 484912 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][CH2:9][N:10]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[C:12]([NH:19][CH2:20][CH2:21][CH2:22][N:23]([CH2:26][CH3:27])[CH2:24][CH3:25])=[N:11]2)[CH2:3][CH2:2]1.[ClH:28].C(OCC)C>C(O)C>[ClH:28].[ClH:28].[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][CH2:9][N:10]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[C:12]([NH:19][CH2:20][CH2:21][CH2:22][N:23]([CH2:26][CH3:27])[CH2:24][CH3:25])=[N:11]2)[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 132105721-(3-Morpholinopropyl)-3-(3-diethylaminopropylamino)indazole

Product 1

HCID 201357991-(3-Morpholinopropyl)-3-(3-diethylaminopropylamino)indazole dihydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 50 ml of absolute ethyl alcohol was dissolved 3.0 g of the 1-(3-morpholinopropyl)-3-(3-diethylaminopropylamino)indazole, and into the solution was introduced dried hydrogen chloride gas under cooling with ice. Then to the solution was added anhydrous diethyl ether to separate crystals. The crystals were obtained by filtration and dried to give 1-(3-morpholinopropyl)-3-(3-diethylaminopropylamino)indazole dihydrochloride having the following analytical value.

Workup

  1. temperatureunder cooling with ice
  2. customto separate crystals
  3. customThe crystals were obtained by filtration
  4. customdried

Sources & evidence

ORD record
ord-d561ce56ab4e476da7d365955c7c15f7
Source dataset
uspto-grants-1985_08
Patent number
US04533731

Reaction notes

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