Hydrochloric Acid → 3-Amino-7-iodoindazole hydrochloride

HRID 484917Notes

Reaction equation

HRID 484917 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[C:6]([I:11])[CH:7]=[CH:8][CH:9]=2)[NH:4][N:3]=1.[ClH:12].C(OCC)C>C(O)C>[ClH:12].[NH2:1][C:2]1[C:10]2[C:5](=[C:6]([I:11])[CH:7]=[CH:8][CH:9]=2)[NH:4][N:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 201358107-iodo-1H-indazol-3-amine

Product 1

HCID 201358223-Amino-7-iodoindazole hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 50 ml of absolute ethyl alcohol was dissolved 3.6 g of the 3-amino-7-iodoindazole, and into the solution was introduced dried hydrogen chloride gas under cooling with ice. Then to the solution was added anhydrous diethyl ether to separate crystals. The crystals were obtained by filtration and dried to give 3-amino-7-iodoindazole hydrochloride having the following analytical value.

Workup

  1. temperatureunder cooling with ice
  2. customto separate crystals
  3. customThe crystals were obtained by filtration
  4. customdried

Sources & evidence

ORD record
ord-8a70b0f4be074f3db83106a2dd0ddd32
Source dataset
uspto-grants-1985_08
Patent number
US04533731

Reaction notes

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