HCID 86740233, compound → HCID 86740231, compound

HRID 484929Notes

Reaction equation

HRID 484929 reaction equation
[N:1]#[N:2].C(OC([N:10]([CH2:25][CH3:26])[C@@H:11]([C:13]([NH:15][CH2:16][CH2:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:14])[CH3:12])=O)(C)(C)C>C(OCC)(=O)C.Cl>[N:1]#[N:2].[CH2:25]([NH:10][C@@H:11]([C:13]([NH:15][CH2:16][CH2:17][CH2:18][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)=[O:14])[CH3:12])[CH3:26]

Participants

3

Reactant 1

HCID 86740233HCID 86740233, compound

Product 1

HCID 86740231HCID 86740231, compoundYield 103.9%

Reagents, catalysts & solvents 1

HCID 21866389Hydrogen chloride-ethyl acetateSolvent

Procedure

A solution of N2 -(tert-butyloxycarbonyl)-N2 -ethyl-N-(3-phenylpropyl)-D-alaninamide (4.28 g.) in hydrogen chloride-ethyl acetate (3.9N, 35 ml.) was stirred for twenty minutes at room temperature, then concentrated. The residue was stripped of volatiles under vacuum (0.1 mm.) at room temperature, affording N2 -ethyl-N-(3-phenylpropyl)-D-alaninamide (3.22 g.).

Workup

  1. concentrationconcentrated
  2. customwas stripped of volatiles under vacuum (0.1 mm.) at room temperature

Sources & evidence

ORD record
ord-77259e775e1441749949fc81b90a16d8
Source dataset
uspto-grants-1985_08
Patent number
US04533655

Reaction notes

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