HuagongsheHuagongshe Chemistry Print Report · For research reference only
N2 (tert-butyloxycarbonyl)-N2-methyl-N-[3-(4-fluorophenyl)propyl]-D-alaninamide → N2 methyl-N-[3-(4-fluorophenyl)propyl]-D-alaninamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N2 (tert-butyloxycarbonyl)-N2-methyl-N-[3-(4-fluorophenyl)propyl]-D-alaninamide | HCID 86740236 | — |
| Solvent | Hydrogen chloride-ethyl acetate | HCID 21866389 | — |
| Product | N2 methyl-N-[3-(4-fluorophenyl)propyl]-D-alaninamide | HCID 86740238 | — |
Reaction Steps
A solution of N2 -(tert-butyloxycarbonyl)-N2 -methyl-N-[3-(4-fluorophenyl)propyl]-D-alaninamide (2.77 g.) in hydrogen chloride-ethyl acetate (3.4N, 15 ml.) was stirred for thirty minutes at room temperature, then concentrated, affording N2 -methyl-N-[3-(4-fluorophenyl)propyl]-D-alaninamide as a crystalline solid (2.06 g., m.r. 148°-150° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04533655 |
| Source dataset | uspto-grants-1985_08 |
| ORD ID | ord-a1c486ace1394ca3adea4e43c35df10b |
| Source note | uspto-grants-1985_08 |