HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → Ethyl 2-(2-phenyl-5-isopropyl-4-oxazolyl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Ethyl 3-benzoylamino-3-isobutyrylpropionate | HCID 13488802 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ethyl 2-(2-phenyl-5-isopropyl-4-oxazolyl)acetate | HCID 13488807 | 82% |
Reaction Steps
6.5 g of ethyl 3-benzoylamino-3-isobutyrylpropionate, 30 ml of dimethylformamide and 4.8 g of phosphorus oxychloride are treated in the same manner as described in Example 1. 5.0 g of ethyl 2-(2-phenyl-5-isopropyl-4-oxazoly)acetate are thereby obtained. Yield: 81.4%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04535089 |
| Source dataset | uspto-grants-1985_08 |
| ORD ID | ord-67ebcf82fdb7482fa0377ebd2f77755b |
| Source note | uspto-grants-1985_08 |