Phosphorus oxychloride → Ethyl 2-(2-phenyl-5-isopropyl-4-oxazolyl)acetate

HRID 485004Notes

Reaction equation

HRID 485004 reaction equation
[C:1]([NH:9][CH:10]([C:17](=[O:21])[CH:18]([CH3:20])[CH3:19])[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.P(Cl)(Cl)(Cl)=O>CN(C)C=O>[C:2]1([C:1]2[O:21][C:17]([CH:18]([CH3:19])[CH3:20])=[C:10]([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:9]=2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 13488802Ethyl 3-benzoylamino-3-isobutyrylpropionate

Product 1

HCID 13488807Ethyl 2-(2-phenyl-5-isopropyl-4-oxazolyl)acetateYield 82%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

6.5 g of ethyl 3-benzoylamino-3-isobutyrylpropionate, 30 ml of dimethylformamide and 4.8 g of phosphorus oxychloride are treated in the same manner as described in Example 1. 5.0 g of ethyl 2-(2-phenyl-5-isopropyl-4-oxazoly)acetate are thereby obtained. Yield: 81.4%.

Sources & evidence

ORD record
ord-67ebcf82fdb7482fa0377ebd2f77755b
Source dataset
uspto-grants-1985_08
Patent number
US04535089

Reaction notes

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