Methanol → 2-(2-Phenyl-5-isopropyl-4-oxazolyl)acetic acid

HRID 485010Notes

Reaction equation

HRID 485010 reaction equation
[C:1]1([C:7]2[O:8][C:9]([CH:18]([CH3:20])[CH3:19])=[C:10]([CH2:12][C:13]([O:15]CC)=[O:14])[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CO.[OH-].[K+]>O>[C:1]1([C:7]2[O:8][C:9]([CH:18]([CH3:20])[CH3:19])=[C:10]([CH2:12][C:13]([OH:15])=[O:14])[N:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 14797Potassium HydroxideHCID 13488807Ethyl 2-(2-phenyl-5-isopropyl-4-oxazolyl)acetate

Product 1

HCID 134888142-(2-Phenyl-5-isopropyl-4-oxazolyl)acetic acidYield 97.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2.73 g of ethyl 2-(2-phenyl-5-isopropyl-4-oxazolyl)acetate, 20 ml of methanol, 5 ml of water and 1.1 g of potassium hydroxide are treated in the same manner as described in Example 8. 2.39 g of 2-(2-phenyl-5-isopropyl-4-oxazolyl)acetic acid are thereby obtained. Yield: 97.4%.

Sources & evidence

ORD record
ord-b204aa53965e4d9fb3ccb7c43ef0fd10
Source dataset
uspto-grants-1985_08
Patent number
US04535089

Reaction notes

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