Methanol → [2-(4-Chlorophenyl)-5-pentyl-1,3-oxazol-4-yl]acetic acid

HRID 485014Notes

Reaction equation

HRID 485014 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[C:11]([CH2:13][C:14]([O:16]CC)=[O:15])[N:12]=2)=[CH:4][CH:3]=1.CO.[OH-].[K+]>O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:9][C:10]([CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[C:11]([CH2:13][C:14]([OH:16])=[O:15])[N:12]=2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 14797Potassium HydroxideHCID 13488812Ethyl [2-(4-chlorophenyl)-5-pentyl-1,3-oxazol-4-yl]acetate

Product 1

HCID 13488818[2-(4-Chlorophenyl)-5-pentyl-1,3-oxazol-4-yl]acetic acidYield 87.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1.0 g of ethyl 2-[2-(4-chlorophenyl)-5-n-pentyl-4-oxazolyl]acetate, 10 ml of methanol, 3 ml of water and 0.4 g of potassium hydroxide are treated in the same manner as described in Example 8. 0.8 g of 2-[2-(4-chlorophenyl)-5-n-pentyl-4-oxazolyl]acetic acid are thereby obtained. Yield: 87.2%.

Sources & evidence

ORD record
ord-0e3ca73e0316466884144eae2823e5c2
Source dataset
uspto-grants-1985_08
Patent number
US04535089

Reaction notes

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