Diethyl (ethoxymethylene)malonate → HCID 5159075, compound

HRID 485135Notes

Reaction equation

HRID 485135 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([CH3:10])([CH3:9])[CH3:8])[N:6]=1.C(O[CH:14]=[C:15]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[C:16]([O:18][CH2:19][CH3:20])=[O:17])C>>[C:21]([C:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:14][NH:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([CH3:10])([CH3:9])[CH3:8])[N:6]=1)([O:23][CH2:24][CH3:25])=[O:22]

Participants

3

Reactant 2

HCID 6871Diethyl (ethoxymethylene)malonateHCID 27342024-tert-Butyl-1,3-thiazol-2-amine

Product 1

HCID 5159075HCID 5159075, compound

Procedure

2-Amino-4-(2-methyl-2-propyl)thiazole (15.6 g., 0.1 mole) and diethyl ethoxymethylenemalonate (23.8 g., 0.11 mole) were combined and heated on a steam bath for 2 hours. 2-(2,2-Dicarbethoxyethenylamino)-4-(2-methyl-2-propyl)thiazole was obtained as a wet solid on cooling and used directly in the next step.

Workup

  1. temperatureheated on a steam bath for 2 hours

Sources & evidence

ORD record
ord-08dda89f146640819cdd8975dba07013
Source dataset
uspto-grants-1985_08
Patent number
US04535081

Reaction notes

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