反应详情

A mixture of 1.0 g. of chloroacetonitrile, 2.2 g. of potassium iodide and 25 ml. of acetone was stirred at room temperature for 1 hour and then, 3.5 g. of N-(4-bromo-3-hydroxyphenyl)-3,4,5,6-tetrahydrophthalimide and 1.8 g. of potassium carbonate were added and the mixture was refluxed with stirring for 5 hours. The solvent was distilled off under a reduced pressure and 2N-HCl was added to the residue to precipitate the product. The precipitate was separated by a filtration and washed with water and dried and recrystallized from ethanol to obtain 2.7 g. of Compound No. 229 shown in Table 1.

1. additionA mixture of 1.0 g
2. temperaturethe mixture was refluxed
3. distillationThe solvent was distilled off under a reduced pressure and 2N-HCl
4. additionwas added to the residue
5. customto precipitate the product
6. customThe precipitate was separated by a filtration
7. washwashed with water
8. customdried
9. customrecrystallized from ethanol
10. customto obtain 2.7 g