反应详情

A mixture of 17.4 g. of 2-chloro-5-nitrophenol, 19.0 g. of ethyl α-bromopropionate, 15.2 g. of potassium carbonate and 85 ml. of acetone was refluxed with stirring for 3.5 hours and the solvent was distilled off. 2N-HCl was added to the residue to obtain a crude crystal. The product was separated by a filtration and washed with water and dried and recrystallized from n-hexane to obtain 27.4 g. of the object compound (melting point of 46° to 46.5° C.).

1. additionA mixture of 17.4 g
2. distillationthe solvent was distilled off
3. addition2N-HCl was added to the residue
4. customto obtain a crude crystal
5. customThe product was separated by a filtration
6. washwashed with water
7. customdried
8. customrecrystallized from n-hexane
9. customto obtain 27.4 g