Water → p-Toluenesulfonic acid

Participants

Reaction Steps

To 4-(2-phenylethenyl)-3-(2-methoxycarbonyl-1-methylethenyl)amino-N-di(p-anisyl)methyl-2-azetizinone (58.7 g) in dioxane (1,174 ml) were added p-toluenesulfonic acid monohydrate (23.96 g) and water (12.4 ml) and stood overnight at room temperature. The mixture was cooled with ice-water, and precipitates were collected by filtration and dried under reduced pressure to give a white powder of 4-(2-phenylethenyl)-3-amino-N-di(p-anisyl)methyl-2-azetizinone, p-toluenesulfonic acid salts. m.p. 172°-174° C.

Provenance & Evidence