Water → p-Toluenesulfonic acid

HRID 485218Notes

Reaction equation

HRID 485218 reaction equation
O.[C:2]1([CH3:12])[CH:7]=[CH:6][C:5]([S:8]([OH:11])(=[O:10])=[O:9])=[CH:4][CH:3]=1.O>O1CCOCC1>[C:2]1([CH3:12])[CH:3]=[CH:4][C:5]([S:8]([OH:11])(=[O:9])=[O:10])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 962WaterHCID 521998p-Toluenesulfonic acid monohydrate

Product 1

HCID 6101p-Toluenesulfonic acid

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To 4-(2-phenylethenyl)-3-(2-methoxycarbonyl-1-methylethenyl)amino-N-di(p-anisyl)methyl-2-azetizinone (58.7 g) in dioxane (1,174 ml) were added p-toluenesulfonic acid monohydrate (23.96 g) and water (12.4 ml) and stood overnight at room temperature. The mixture was cooled with ice-water, and precipitates were collected by filtration and dried under reduced pressure to give a white powder of 4-(2-phenylethenyl)-3-amino-N-di(p-anisyl)methyl-2-azetizinone, p-toluenesulfonic acid salts. m.p. 172°-174° C.

Workup

  1. customprecipitates
  2. filtrationwere collected by filtration
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-80e2f9b83bf94ecc8e437ed5010692db
Source dataset
uspto-grants-1985_08
Patent number
US04536334

Reaction notes

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