反应详情

A solution of 15 g. of 3-(4-methylphenyl)propionyl chloride in 100 ml. of dichloromethane is created with stirring with a solution of 15 g. of benzocaine and 9.13 g. of triethylamine in 100 ml. of dichloromethane. The mixture is stirred overnight, then washed with 100 ml. each of 10% hydrochloric acid, water, and brine, then dried with magnesium sulfate, and evaporated to yield a solid. This solid is crystallized from 200 ml. of acetonitrile and dried in vacuo, giving 22.08 g. of the desired product, m.p. 154°-155° C.

1. stirringThe mixture is stirred overnight
2. washwashed with 100 ml
3. dry with materialeach of 10% hydrochloric acid, water, and brine, then dried with magnesium sulfate
4. customevaporated
5. customto yield a solid
6. customThis solid is crystallized from 200 ml
7. dry with materialof acetonitrile and dried in vacuo
8. customgiving 22.08 g