反应详情

To a 10 g (30 mmols) portion of 4-(3-phthalimidopropyl)benzonitrile were added 1.89 ml (39 mmols) of hydrazine hydrate and 130 ml of methanol, and the mixture was refluxed for 3 hours, cooled to room temperature and then concentrated. The residue was dissolved in 200 ml of 1 mol dm-3NaOH, followed by extraction with ether. The extract was dried over K2CO3 and concentrated, giving 4.32 g (yield 90%) of 4-(3-aminopropyl)benzonitrile.

1. temperaturethe mixture was refluxed for 3 hours
2. concentrationconcentrated
3. dissolutionThe residue was dissolved in 200 ml of 1 mol dm-3NaOH
4. extractionfollowed by extraction with ether
5. dry with materialThe extract was dried over K2CO3
6. concentrationconcentrated