HRID485331

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11776

Triphenylphosphine

C18H15P

HCID5462977

(E)-Diethyl azodicarboxylate

C6H10N2O4

HCID54130108

未命名化合物

结构：CCOC(=O)CCN(CC)C(=O)N1C[C@H](O)C[C@H]1C(=O)OCc1ccccc1

HCID131714305

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)CCN(CC)C(=O)N1C[C@@H](Oc2ccc(C=COC)cc2)C[C@H]1C(=O)OCc1ccccc1

HCID131714306

未命名化合物

PROCEDURE

实验过程

Equimolar amounts of (trans)-1-[[(3-ethoxy-3-oxopropyl)ethylamino]carbonyl]-4-hydroxy-L-proline, phenylmethyl ester and 4-(2-methoxyethenyl)phenol are reacted in the presence of triphenylphosphine and diethylazodicarboxylate to give (cis)-4-[4-(2-methoxyethenyl)phenoxy]-1-[[(3-ethoxy-3-oxopropyl)ethylamino]carbonyl]-L-proline, phenylmethyl ester.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0851be4a195641449d20ec9c03817185
来源数据集: uspto-grants-1985_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04536501
来源说明: uspto-grants-1985_08

反应 SMILES

[CH2:1]([O:3][C:4](=[O:28])[CH2:5][CH2:6][N:7]([CH2:26][CH3:27])[C:8]([N:10]1[CH2:24][C@H:23]([OH:25])[CH2:22][C@H:11]1[C:12]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:13])=[O:9])[CH3:2].[CH3:29][O:30][CH:31]=[CH:32][C:33]1[CH:38]=[CH:37][C:36](O)=[CH:35][CH:34]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.CCOC(/N=N/C(OCC)=O)=O>>[CH3:29][O:30][CH:31]=[CH:32][C:33]1[CH:38]=[CH:37][C:36]([O:25][C@@H:23]2[CH2:24][N:10]([C:8]([N:7]([CH2:6][CH2:5][C:4]([O:3][CH2:1][CH3:2])=[O:28])[CH2:26][CH3:27])=[O:9])[C@H:11]([C:12]([O:14][CH2:15][C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)=[O:13])[CH2:22]2)=[CH:35][CH:34]=1