HRID485333

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11776

Triphenylphosphine

C18H15P

HCID54130108

未命名化合物

结构：CC(C)COC(=O)N1C[C@H](O)C[C@H]1C(=O)OC(c1ccccc1)c1ccccc1

HCID131714309

未命名化合物

PRODUCTS

生成物

结构：COC=Cc1ccc(O[C@H]2C[C@@H](C(=O)OC(c3ccccc3)c3ccccc3)N(C(=O)OCC(C)C)C2)cc1

HCID131714308

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID241

Benzene

C6H6

PROCEDURE

实验过程

A mixture of 1-[(2,2-dimethylethoxy)carbonyl]-(trans)-4-hydroxy-L-proline, diphenylmethyl ester, triphenylphosphine, and 4-(2-methoxyethenyl)phenol is taken up in benzene and evaporated to dryness. The residue is dissolved in dry tetrahydrofuran, cooled to -10° under argon, and treated with diethylazodicarboxylate. The reaction mixture is worked up according to the procedure of Example 1(b) to yield 1-[(2,2-dimethylethoxy)carbonyl]-(cis)-4-[4-(2-methoxyethenyl)phenoxy]-L-proline, diphenylmethyl ester.

WORKUP

后处理

customevaporated to dryness
dissolutionThe residue is dissolved in dry tetrahydrofuran
temperaturecooled to -10° under argon
additiontreated with diethylazodicarboxylate

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8980026a705e4fcd9c2d5f90a66b9b94
来源数据集: uspto-grants-1985_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04536501
来源说明: uspto-grants-1985_08

反应 SMILES

[CH3:1][CH:2]([CH3:29])[CH2:3][O:4][C:5]([N:7]1[CH2:27][C@H:26]([OH:28])[CH2:25][C@H:8]1[C:9]([O:11][CH:12]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:10])=[O:6].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[CH3:49][O:50][CH:51]=[CH:52][C:53]1[CH:58]=[CH:57][C:56](O)=[CH:55][CH:54]=1>C1C=CC=CC=1>[CH3:1][CH:2]([CH3:29])[CH2:3][O:4][C:5]([N:7]1[CH2:27][C@@H:26]([O:28][C:56]2[CH:57]=[CH:58][C:53]([CH:52]=[CH:51][O:50][CH3:49])=[CH:54][CH:55]=2)[CH2:25][C@H:8]1[C:9]([O:11][CH:12]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)=[O:10])=[O:6]