反应详情

A solution of 7.38 g of 3-indolepropionic acid and 5.9 g of thionyl chloride in 50 ml of ethanol is refluxed for 2 hours, cooled and evaporated. The residue is partitioned between ether and cold sodium bicarbonate solution. The organic phase is separated, dried over sodium sulfate and evaporated to yield ethyl 3-(3-indolyl)propionate; Rf (ether/SiO2)=0.51; IR (CH2Cl2) 1725 cm-1.

1. temperaturecooled
2. customevaporated
3. customThe residue is partitioned between ether and cold sodium bicarbonate solution
4. customThe organic phase is separated
5. dry with materialdried over sodium sulfate
6. customevaporated