反应详情

A solution of 1.1 g of 3-[2-(ethoxycarbonyl)-prop-1-enyl)-N-(3-pyridyl)indole, and 0.288 g of sodium hydroxide in 10 ml of methanol and 10 ml of water is heated under reflux for 2 hours, cooled and evaporated. The resulting oil is redissolved in 10 ml of ice water and is neutralized with 0.59 ml of concentrated hydrochloric acid. The resulting solid is filtered and dried to yield 3-(2carboxyprop-1-enyl)-N-(3-pyridyl)indole, m.p. 213°-215°.

1. temperatureunder reflux for 2 hours
2. temperaturecooled
3. customevaporated
4. dissolutionThe resulting oil is redissolved in 10 ml of ice water
5. filtrationThe resulting solid is filtered
6. customdried