HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 3-(2carboxyprop-1-enyl)-N-(3-pyridyl)indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-[2-(ethoxycarbonyl)prop-1-enyl]-N-(3-pyridyl)indole | HCID 53918156 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-(2carboxyprop-1-enyl)-N-(3-pyridyl)indole | HCID 54542603 | — |
Reaction Steps
A solution of 1.1 g of 3-[2-(ethoxycarbonyl)-prop-1-enyl)-N-(3-pyridyl)indole, and 0.288 g of sodium hydroxide in 10 ml of methanol and 10 ml of water is heated under reflux for 2 hours, cooled and evaporated. The resulting oil is redissolved in 10 ml of ice water and is neutralized with 0.59 ml of concentrated hydrochloric acid. The resulting solid is filtered and dried to yield 3-(2carboxyprop-1-enyl)-N-(3-pyridyl)indole, m.p. 213°-215°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04536505 |
| Source dataset | uspto-grants-1985_08 |
| ORD ID | ord-7fda04becbe44a579bd74c36533edeea |
| Source note | uspto-grants-1985_08 |