反应详情

A solution of hydroxylamine (from 2.06 g of hydroxylamine hydrochloride and 2.02 g of sodium hydroxide) and 7.6 g of 3-(4-methoxycarbonylbutyl)-N-(3-pyridyl)indole in 25 ml of methanol is allowed to stand at room temperature for 20 hours. The methanol is evaporated and the residue is taken up in 5 ml of water and adjusted to pH=7. The mixture is extracted with methylene chloride, the extract is washed with water, dried and evaporated to dryness yielding 3-[4-(hydroxycarbamoyl)butyl]-N-(3-pyridyl)indole.

1. customThe methanol is evaporated
2. extractionThe mixture is extracted with methylene chloride
3. washthe extract is washed with water
4. customdried
5. customevaporated to dryness