Toluene → HCID 13072183, compound

HRID 485366Notes

Reaction equation

HRID 485366 reaction equation
[Al+3].[Cl-].[Cl-].[Cl-].[C:5]1([CH:11](O)[CH2:12][N:13]2[CH:17]=[N:16][CH:15]=[N:14]2)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[C:19]1([CH3:25])[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>ClCCCl>[CH3:25][C:19]1[CH:24]=[CH:23][C:22]([CH:11]([C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH2:12][N:13]2[CH:17]=[N:16][CH:15]=[N:14]2)=[CH:21][CH:20]=1

Participants

5

Reactant 3

HCID 1140TolueneHCID 6451240Aluminum(III) ChlorideHCID 10081198HCID 10081198, compound

Product 1

HCID 13072183HCID 13072183, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Conditions

Temperature
80 °C

Procedure

20 g (0.15 mole) of AlCl3 were added in portions to a solution of 18.9 g (0.1 mole) of 1-phenyl-2-(1,2,4-triazol-1-yl)-ethanol in 50 ml of toluene and 50 ml of 1,2-dichloroethane at -10° C. Thereafter, the mixture was heated to 80° C., until the evolution of gas was no longer observed. The mixture was poured onto 200 ml of ice-water, the organic phase was separated off and concentrated, and the residue was triturated with diisopropyl ether. Yield 23.8 g (90%), m.p. 98°-100° C.

Workup

  1. customthe organic phase was separated off
  2. concentrationconcentrated
  3. customthe residue was triturated with diisopropyl ether

Sources & evidence

ORD record
ord-c560ee900a2b45038f0ca918b7c5d213
Source dataset
uspto-grants-1985_08
Patent number
US04536509

Reaction notes

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