反应详情

Benzoyl chloride (0.88 ml, 7.6 mmol) was added to a stirred suspension of pregabalin (1.0 g, 6.3 mmol) in THF (80 ml) at room temperature under argon and the reaction mixture was stirred for 18 hours. The reaction mixture was then filtered and concentrated in vacuo. The residue was chromatographed (SiO2, heptane-ethyl acetate, 1:1 to 3:7) to give 4 (0.78 g, 47%).

1. filtrationThe reaction mixture was then filtered
2. concentrationconcentrated in vacuo
3. customThe residue was chromatographed (SiO2, heptane-ethyl acetate, 1:1 to 3:7)